Pooled CRISPRa Libraries

CRISPRa targeted gene activation provides alternative genetic screening approaches to identify genes whose activation initiate a response, a so called gain of-function screen. CRISPRa libraries that activate endogenous gene expression, make use of engineered versions of deactivated Cas9 (dCas9) which have proven to be effective modulators of gene expression when complexed with activator proteins, e.g., dCas9-VPH.
Nucleus Biotech provides Cellecta´s pre-made, pooled lentiviral libraries targeting the promoter regions of all human or mouse protein-coding genes.
Unique are Cellecta´s Dual sgRNA CRISPRa libraries:  Targeting each gene with two sgRNAs for its promoter region means stronger activation.

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