Cas9 Expression Cell Lines

CRISPR knockout requires expression of both a single-guide RNA (sgRNA) that targets the specific site for knockout, and expression of the Cas9 nuclease which cuts the DNA at the target site. Also, for studies using the CRISPRa or CRISPRi systems, cells need to express the corresponding dCas9 activator (e.g. dCas9-VPH or dCas9-VPR) or dCas9-repressor (e.g. dCas9-KRAB). For many CRISPR applications then, it is useful or necessary to have cells stably expressing one of the the Cas9 proteins.

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MDA-MB-231 CRISPR Cells stably expressing Cas9

Cat.#: ZMDAMB231-C9

Qty.: Quantity: 10^6 cells

MDA-MB-231 cells expressing Cas9 (S. pyogenes). For use as a validated high Cas9 expression cell line in CRISPR studies or as a control with CRISPRTest Cas9 act...

MDA-MB-231 CRISPRi Cells stably expressing dCas9-KRAB

Cat.#: ZMDAMB231-CKRA

Qty.: Quantity: 10^6 cells

MDA-MB-231 cells expressing dCas9-KRAB (S. pyogenes). For use as a validated high dCas9-KRAB expression cell line in CRISPRi studies or as a control with CRISPR...

MDA-MB-231 CRISPRa Cells stably expressing dCas9-VPH

Cat.#: ZMDAMB231-CVPH

Qty.: Quantity: 10^6 cells

MDA-MB-231 cells expressing dCas9-VPH (S. pyogenes). For use as a validated high dCas9-VPH expression cell line in CRISPRa studies or as a control with CRISPRaT...

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