Super high amplification uniformity and super low PCR background noise (more accurate variant calling and less sequencing cost)
Single-tube and 3-hour workflow with minimal hands-on time (easy automation)
Compatible with difficult samples (degraded FFPE DNA & RNA, cfDNA & cfRNA) and major platforms (Illumina, Ion Torrent, Genapsys, MGI DNBSeq)
Extreme sensitivity (down to single cell level direct amplification)
Excellent panel size scalability from a few to over 20,000 amplicons in a single multiplex PCR pool
Detection of and analysis for single nucleotide variants (SNVs), small insertions and deletions (Indels), copy number variations (CNVs), gene fusions / splice variants, gene expression level, tumor mutational burden (TMB), microsatellite instability (MSI), internal tandem duplication (ITD), etc
View data on CleanPlex® technology for amplicon sequencing:
OmniFusion RNA Lung Cancer: Detection of more than 530 known and also of unknown RNA fusions associated with non-small cell lung cancer
AccuFusion RNA Lung Cancer: Focused detection of more than 280 known gene fusions associated with non-small cell lung cancer
Hereditary Cancer: For analyzing 37 genes (for both, single nucleotide variants – SNVs-, and insertion-deletion mutations -indels-), associated with an increased risk of developing hereditary cancers.
Mitochondrial Diseases: Evaluation of the entire human mitochondrial genome for mutations. Complete coverage of all 37 genes of the ~17 kb mitochondrial genome, allowing identification of important variants.
Cystic Fibrosis: Evaluation of germline variants across the CFTR gene