SARS-CoV-2 Host Cell Entry Factor Expression Cell Lines

Our partner Cellecta has developed HeLa and U2OS stable cell lines, overexpressing the host entry factors ACE2 and DPP4. These cells are susceptible to infection by viruses expressing the SARS virus spike protein, including SARS-CoV2-S and SARS-CoV2-S-D614G pseudotyped lentivirus. They can be used for in vitro screening and characterization of drug candidates,  neutralization assays, and related approaches studying viral binding.