SARS-CoV-2 Spike-Protein Pseudotyped Lentiviral Particles

Since SARS and MERS coronaviruses are pathogenic, research on them requires bio-safety level-3 procedures, which can be difficult to carry out in commercial and university laboratories. An alternative approach is to pseudotype lentiviral particles with the coronavirus coat proteins. This enables researchers to carry out studies on these viral elements in S2 laboratories.

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