B18R mRNA

Description

Ready-to-use synthetic B18R mRNA

For in vitro mRNA transfection and in vivo mRNA delivery by injection

Encodes the vaccinia virus-derived type I interferon decoy receptor B18R, which transiently neutralizes IFN-α/β to enhance recombinant protein production and cell viability by suppressing host antiviral responses. This synthetic mRNA is optimized for applications in mRNA vaccine production (inhibiting PKR-mediated translation suppression), stem cell reprogramming (reducing IFN-induced differentiation), and oncolytic virus research (modulating immunogenicity), with its transient expression profile (48-72h) providing precise temporal control over IFN inhibition compared to stable protein additives

Manufactured by Levostar´s monoPlasmid technology

Designed for optimal expression results:

• Enhanced polyA(+) Stability – for preventing RNA degradation

• Cap1 Structure – for optimal ribosome recruiting

• Carefully selected UTR Regions – to enhance translation initiation

Quality Standards: Tested for high purity, low endotoxin,  low residual dsRNA & plasmid template DNA, high capping efficiency, and proper polyA(+)-length.

Contents:  1 mg mRNA, lyophilized          – also available in solution (1 mg/ml), please inquire

Shipping and Storage:   Lyophilized mRNA shipped at room temperature (≤ 25°C). Store at –80°C upon dissolving.

For other mRNA quantities than 1 mg including bulk offers please contact us for pricing

mRNA may also be ordered already encapsulated in Lipid Nanoparticles for high efficiency mRNA delivery – please contact us for a quotation.

For mRNA encapsulation in your lab and subsequent in vitro mRNA transfection or in vivo mRNA delivery we offer Levostar´s portfolio of NeoLNP Kits.