Description
Magnetic DNA Normalization Beads – Normalize NGS Libraries, PCR Products, or sheared genomic DNA
Bead-based DNA Normalization
- Consistent DNA quantity normalization of various sources in excellent dynamic range
- Easy and efficient protocol – no centrifugation, no filtering
- No more fluorescent quantitation needed
- Cost and Time Saving
- Removal of unwanted components and impurities
- Elution in as low as 10 µl without yield loss
- Ideal for High Throughput Sample Processing
| NGS Library, PCR Fragment, Sheared Genomic DNA | |
| DNA Input | 150 ng – 1200 ng |
| Normalized Range | 100 ng – 320 ng |
| Elution Volume | >10 ul |
During bead-based normalization, DNA samples of varying concentrations are bound to BioDynami´s magnetic DNA normalization beads characterized by a defined limited DNA binding capacity. Bound DNAs are subsequently eluted off the beads at approximately the same concentration for each sample.
NGS Library Normalization with BioDynami´s Magnetic DNA Normalization Beads:
Magnetic bead-based NGS library normalization provides significant cost and time savings especially when processing many samples.
This efficient, time-saving alternative bypasses time-consuming and costly library quantitation measurements using fluorescence and/or fragment analyzer instruments. Moreover, manual pipetting steps including dilutions before loading NGS libraries onto the sequencer are no longer necessary.

Normalization of NGS libraries: The input NGS library amount and normalized NGS library amount are shown.
Kit Components: 0.4 ml Magnetic DNA Normalization Beads, 2 ml Elution Buffer – Sufficient for 96 Runs (based on 40 ul sample volumes)
