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Human CRISPRa Dual-sgRNA Library (UbiC) (DNA)-academia

5.425,00 

Quantity: 200 ug

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Description

Genome-wide pooled library of ~105,000 sgRNA constructs targeting the promoter region of ~19,000 protein-coding human genes. Designed to work with deactivated spCas9 (dCas9) complexed with an activator (e.g., dCas9-VPH) to induce gene expression.
The promoter region of each gene is targeted by 5 sgRNAs in dual combinations of each of the 5 constructs (design based on Horbeck, et al., eLife 2016;5:e19760 DOI: 10.7554). Targeting genes with dual-sgRNA constructs leads to increased gene activation.

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