in vivo NeoLNP RNA Transfection Kit for Lung-Targeted Delivery (0.3 ml)

Description

Lung-targeted LNP-based in vivo transfection of mRNA and siRNA

RNA Encapsulation into LNPs (Lipid Nanoparticles) for high efficiency in vivo lung-targeted transfections

The in vivo NeoLNP™ RNA Transfection Kit for Lung-targeted Delivery is based on Levostar´s ready–to–use NeoLNP lipid nanoparticle (LNP) system, and is tailored for lung-targeted in vivo transfection of mRNA and siRNA in animals, which is enabled by utilizing novel biodegradable lipids for a uniquely efficient transmembrane transport and endosomal escape mechanism, and which are modified for delivery to the lung.

For research use only.

• Easy to Use: Requires no specialized microfluidics equipment – LNP encapsulation occurs in a one minute simple mixing step without additional incubation
• High Encapsulation Efficiency: Achieves up to 80% encapsulation efficiency for micro–volume samples, with transfection results comparable to LNPs prepared using microfluidics
• Lung-targeted mRNA/siRNA administration in animals via intravenous (IV) injections
• Safe and Non Toxic: Formulated without ethanol, using novel biodegradable lipids, and sterilized with 0.2 μm filtration

Kit Contents:

• 0.3 ml in vivo NeoLNP Reagent, 8 ml RNA Dilution Buffer, and 10μg FLuc mRNA as positive control
• Sufficient for 15 mRNA – or siRNA- encapsulations & IV injections in mice

Shipping and Storage:
Shipped at room temperature (≤ 25°C). Store at 2–8°C upon receipt. Avoid freezing.