NR5A2 (LRH-1) mRNA

Description

Ready-to-use synthetic NR5A2 (LRH-1) mRNA

For in vitro mRNA transfection and in vivo mRNA delivery by injection

Encodes the nuclear receptor subfamily 5 group A member 2 (NR5A2, also known as LRH-1), an orphan nuclear receptor that regulates pluripotency gene networks, liver homeostasis, and pancreatic development through transcriptional control of OCT4 and SHH pathways. This synthetic mRNA enables controlled expression of NR5A2 for research in stem cell maintenance, organoid generation (particularly hepatic and intestinal models), and regenerative strategies for metabolic disorders like diabetes

Manufactured by Levostar´s monoPlasmid technology

Designed for optimal expression results:

• Enhanced polyA(+) Stability – for preventing RNA degradation

• Cap1 Structure – for optimal ribosome recruiting

• Carefully selected UTR Regions – to enhance translation initiation

N1-Methylpseudouridine Modification

For enhanced mRNA stability and decreased anti-mRNA immune response Levostar´s catalog mRNAs are in vitro transcribed using N1-Methylpseudouridine (N1-Me-Ψ, N1mpU) by default. If you prefer unmodified mRNA or you require a different modification, please contact us.

Quality Standards: Tested for high purity, and characterized by low endotoxin,  low residual dsRNA & plasmid template DNA, high capping efficiency, and proper polyA(+)-length.

Contents:  1 mg mRNA, lyophilized  – also available in solution (1 mg/ml), please inquire

Shipping and Storage: Lyophilized mRNA shipped on gel packs. Store at –80°C upon arrival and after dissolving.

For other mRNA quantities than 1 mg including bulk offers please contact us for pricing

mRNA may also be ordered already encapsulated in Lipid Nanoparticles for high efficiency mRNA delivery – please contact us for a quotation.

For mRNA encapsulation in your lab and subsequent in vitro mRNA transfection or in vivo mRNA delivery we offer Levostar´s portfolio of NeoLNP Kits.