PDGFRA mRNA

Description

Ready-to-use PDGFRA mRNA

For in vitro mRNA transfection and in vivo mRNA delivery by injection

Encodes the Platelet-Derived Growth Factor Receptor Alpha (PDGFRA), which plays a key role in vascular smooth muscle cell proliferation and blood vessel formation. Mutations in PDGFRA are commonly found in GIST and gliomas, making it an important target for anticancer drugs such as Imatinib and Avapritinib –  for research and development in the context of angiogenesis research, gastrointestinal stromal tumor (GIST) studies, and anti-PDGFR targeted therapy development

Manufactured by Levostar´s monoPlasmid technology

Designed for optimal expression results:

• Enhanced polyA(+) Stability – for preventing RNA degradation

• Cap1 Structure – for optimal ribosome recruiting

• Carefully selected UTR Regions – to enhance translation initiation

N1-Methylpseudouridine Modification

For enhanced mRNA stability and decreased anti-mRNA immune response Levostar´s catalog mRNAs are in vitro transcribed using N1-Methylpseudouridine (N1-Me-Ψ, N1mpU) by default. If you prefer unmodified mRNA or you require a different modification, please contact us.

Quality Standards: Tested for high purity, low endotoxin,  low residual dsRNA & plasmid template DNA, high capping efficiency, and proper polyA(+)-length.

Contents:  1 mg mRNA, lyophilized          – also available in solution (1 mg/ml), please inquire

Shipping and Storage:   Lyophilized mRNA shipped at room temperature (≤ 25°C). Store at –80°C upon dissolving.

For other mRNA quantities than 1 mg including bulk offers please contact us for pricing

mRNA may also be ordered already encapsulated in Lipid Nanoparticles for high efficiency mRNA delivery – please contact us for a quotation.

For mRNA encapsulation in your lab and subsequent in vitro mRNA transfection or in vivo mRNA delivery we offer Levostar´s portfolio of NeoLNP Kits.