Proximo Hi-C Kit for Human Samples – FFPE Module

Proximity ligation is used to trap short-, long-, and ultra-long-range intracellular DNA contacts (black arcs) from tissue, blood, or other sample types. Chimeric junctions originating from the same cell are recovered, converted into a short-read sequencing library, and subjected to paired-end sequencing. The proximity ligation signal increases as the genomic distance between any two loci across the genome decreases. This unique information can be used for genome-wide detection of all major types of chromosomal abnormalities.