TNFR1 (TNFRSF1A) mRNA

Description

Ready-to-use TNFR1 (TNFRSF1A) mRNA

For in vitro mRNA transfection and in vivo mRNA delivery by injection

Encodes TNFR1 , Tumor Necrosis Factor Receptor 1, als known as TNFRSF1A, one of the primary receptors for tumor necrosis factor-alpha (TNF-α) and is widely expressed in most mammalian cells. It plays a critical role in inflammatory responses, apoptosis, necrosis, and autoimmune regulation. TNFR1 mediates activation of the NF-κB signaling pathway and apoptosis/necrosis pathways via TRADD, FADD, and RIPK1 – for research and development in the context of apoptosis research, inflammation and immune signaling pathway studies, mRNA delivery research, cancer, chronic inflammation, and autoimmune diseases such as rheumatoid arthritis and Crohn’s disease

Manufactured by Levostar´s monoPlasmid technology

Designed for optimal expression results:

• Enhanced polyA(+) Stability – for preventing RNA degradation

• Cap1 Structure – for optimal ribosome recruiting

• Carefully selected UTR Regions – to enhance translation initiation

N1-Methylpseudouridine Modification

For enhanced mRNA stability and decreased anti-mRNA immune response Levostar´s catalog mRNAs are in vitro transcribed using N1-Methylpseudouridine (N1-Me-Ψ, N1mpU) by default. If you prefer unmodified mRNA or you require a different modification, please contact us.

Quality Standards: Tested for high purity, low endotoxin,  low residual dsRNA & plasmid template DNA, high capping efficiency, and proper polyA(+)-length.

Contents:  1 mg mRNA, lyophilized          – also available in solution (1 mg/ml), please inquire

Shipping and Storage:   Lyophilized mRNA shipped at room temperature (≤ 25°C). Store at –80°C upon dissolving.

For other mRNA quantities than 1 mg including bulk offers please contact us for pricing

mRNA may also be ordered already encapsulated in Lipid Nanoparticles for high efficiency mRNA delivery – please contact us for a quotation.

For mRNA encapsulation in your lab and subsequent in vitro mRNA transfection or in vivo mRNA delivery we offer Levostar´s portfolio of NeoLNP Kits.