Nucleus Biotech
The core of Life Sciences

Nucleus Biotech is a trusted source of reagents and services empowering life science research across academia and industry. From Gene Synthesis and NGS Kits to RNAi- and CRISPR-based solutions and beyond, we offer a broad portfolio designed to support diverse research workflows. What truly sets us apart is our commitment to close, fast, and personal customer support. We help you find the best-fit solutions for your experimental setup, keep you informed every step of the way, and ensure your project runs smoothly from start to finish.

Nucleus Biotech HQ

At a Glance

Founded

January of 2020

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Location

Heidelberg, Germany

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Customers

Academia & Industry

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Focus

Reagents & Services

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What We Do

At Nucleus Biotech, we provide enabling reagents and services that power life science research in both academia and industry. As a specialized distributor and scientific partner, we bring together a comprehensive portfolio of cutting-edge tools – from CRISPR genome editing and NGS library preparation to custom gene synthesis and immunogenomics solutions. Whether you’re optimizing routine lab workflows or tackling complex challenges like target discovery screens, liquid biopsy analyses, or high-throughput functional genomics projects, we’re here to support you every step of the way. Our team doesn’t just deliver products—we provide expert guidance, helping you select the right tools, troubleshoot experimental setups, and navigate even the most demanding applications with confidence.

CRISPR Tools

Complete solutions for genome engineering, including pooled and arrayed lentiviral sgRNA libraries, Cas proteins and mRNA, and synthetic gRNA – for CRISPR knockout, activation, inhibition, Perturb-Seq applications, as well as CRISPRDx.

Gene Synthesis Services

Custom gene and gene fragment synthesis with documented sequence verification, flexible vector options, and optional large scale high purity plasmid preparation – paired with competitive pricing and excellent support from request to delivery.

Next Generation Sequencing

Broad NGS portfolio featuring immune repertoire profiling, amplicon and hybridization capture panels, long-read sequencing, Hi-C kits, microbiome profiling, and library prep solutions for DNA and RNA applications.

RNA Genomics

Advanced RNA analysis tools including small RNA-seq, targeted RNA-seq and RBP targetome sequencing. Premade and customized synthetic mRNAs, circRNAs, saRNAs, and LNP-based RNA delivery solutions.

Immunogenomics

Next-generation solutions for adaptive immune system research: Bulk and single-cell TCR & BCR sequencing for clonotype screening as well as obtaining chain pairing information. Services for receptor chain synthesis and cloning, Engineered reporter cell systems for detecting antigen-receptor interactions. Synthetic mRNAs for expression of antibody-, CAR-, and ADC-targets.

Liquid Biopsy

Specialized kits and reagents for non-invasive biomarker detection from blood and body fluids, including sample collection tubes, cf-DNA/RNA isolation, exosome purification, cf-RNA seq kits, and sensitive NGS panels for cancer mutation detection.

Lentiviral Systems

High-efficiency lentiviral tools for stable expression in any cell type: Packaging, concentration, and transduction reagents, cloning vectors, production services, and genome-wide shRNA, sgRNA, and ORF libraries as well as individual lentiviral expression constructs and clones.

Cell Barcoding

Lentiviral barcode libraries for lineage tracing, cell fate mapping, and high-throughput screening – compatible with genomic DNA and RNA-seq readouts.

Sample Collection

Innovative iSWAB devices for non-invasive collection and room-temperature preservation of microbiomes, DNA, RNA, and cells, plus HemaSure-OMICS all-in-one liquid biopsy tubes for blood collection and preservation of cf-DNA and cells at room temperature.

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Our Team

We’re a small customer-centric team, and that’s by choice. At Nucleus Biotech, you won’t navigate through layers of sales reps or support tickets. Instead, you work directly with people who know the science, understand the products, and have spent years in the field. We stay lean so we can stay close – to new technologies, to our customers, and to what actually works in the lab.

Our Management:

[Michael Ehret Image]

Dr. Michael Ehret

Managing Director & Scientific Consultant

Michael has been in the biotech industry since 1986, working his way through Stratagene, Clontech and founding the BioCat GmbH in 2000 – a successful life science distributor he built and sold in 2017. But after nearly 20 years running BioCat, he realized he missed the direct customer contact and closeness to cutting-edge technologies. That’s why he founded Nucleus Biotech in 2020: to get back to what he loves – working hands-on with customers on challenging projects, advising on CRISPR screens, NGS workflows, liquid biopsy setups, and custom gene synthesis, and helping labs figure out which products actually fit their needs. When he’s not scouting for the next innovative technology, Michael is passionate about basketball and his cats and enjoys cultivating local and exotic plants in his garden – including banana trees that, despite his best efforts, haven’t produced edible fruit yet.

[Image Elke Gamer]

Dr. Elke Gamer

Product Manager

Elke studied at the University of Heidelberg and completed her PhD in Molecular Biology, followed by a postdoctoral position at the Institute of Human Genetics. During her PhD and postdoctoral work, she gained comprehensive knowledge across diverse life science disciplines. From there she made the moved from research into the life science supplier sector, motivated to work closely with researchers and staying up to date with the latest methods and innovations in life sciences. Due to her scientific background and the experience gained in customer support and product management roles at Stratagene, Hybaid, and BioCat, she is highly knowledgeable and has developed excellent skills. Elke is your competent partner, supporting you with Nucleus Biotech’s products and services to help facilitate your research. When she’s not helping customers navigate their next experiment, Elke loves dancing, hiking, and long walks with her dog.

Partners & Technology Sources

We partner with companies developing the technologies we believe in—the ones solving challenges in functional genomics, target discovery and biomarker screening. Our job is to bring these advanced methods to labs across Europe and make sure you have our support and assistance to use them successfully.

BioDynami Logo

BioDynami (USA)

NGS Library Preparation

Celemics Logo

Celemics (South Korea)

Hyb-Capture NGS Solutions

Cellecta Logo

Cellecta (USA)

CRISPR/RNAi & Immune Repertoire Profiling

Eclipse Logo

Eclipse BioInnovations (USA)

RNA Genomics Sequencing

Heidelberg Biolabs Logo

Heidelberg Biolabs (Germany)

Cell-free RNA Analysis

Levostar Logo

Levostar (USA & China)

RNA & DNA Synthesis

Mawi Logo

Mawi (USA)

Sample Collection

Nexotech Logo

Nexotech (Spain)

Exosome Purification Kits

Phase Genomics Logo

Phase Genomics (USA)

Hi-C Sequencing Kits

Synbio Logo

Skyang Bio (USA)

Clone Collections & Libraries

BioDynami Logo

BioDynami (USA)

NGS Library Preparation

Celemics Logo

Celemics (South Korea)

Hyb-Capture NGS Solutions

Cellecta Logo

Cellecta (USA)

CRISPR/RNAi & Immune Repertoire Profiling

Eclipse Logo

Eclipse BioInnovations (USA)

RNA Genomics Sequencing

Heidelberg Biolabs Logo

Heidelberg Biolabs (Germany)

Cell-free RNA Analysis

Levostar Logo

Levostar (USA & China)

RNA & DNA Synthesis

Mawi Logo

Mawi (USA)

Sample Collection

Nexotech Logo

Nexotech (Spain)

Exosome Purification Kits

Phase Genomics Logo

Phase Genomics (USA)

Hi-C Sequencing Kits

Synbio Logo

Skyang Bio (USA)

Clone Collections & Libraries

Based in Heidelberg, Serving Europe

Being based in Heidelberg puts us at the heart of one of Europe’s most vibrant life science ecosystems. We’re located in the Business Development Center, part of the Heidelberg Innovation Park, surrounded by young start-ups and innovative companies. This environment gives us direct access to cutting-edge developments like BioLiqX Small RNA-Seq for liquid biopsy analysis and RBP targetome sequencing, developed by our local partner Heidelberg Biolabs. Being embedded in this research-intensive community means we’re constantly connected to what’s happening in the field and can bring the most advanced methods to our customers quickly.

Our approach is guided by a few core principles: First, we believe in honest, direct consultation we’ll tell you upfront which kit, reagent or setup is the right fit for your experimental goals. Second, we’re committed to close, ongoing support. We don’t just ship products; we stay engaged before, during, and after delivery, and are actively interested in how you’re deploying our tools and how your results turn out. Finally, we value scientific rigor and quality in everything we offer – our portfolio is strictly confined to high performance products and services providing solutions and reliable results.

Start Your Next Project with Nucleus Biotech

Whether you’re planning a CRISPR screen, setting up an NGS workflow, or exploring custom gene synthesis – we’re here to help. Browse our portfolio or reach out to discuss your project. We’re happy to answer questions and recommend the right approach for your needs.