Nucleus Biotech
The core of Life Sciences

Nucleus Biotech is a trusted source of reagents and services empowering life science research across academia and industry. From Gene Synthesis and NGS Kits to RNAi- and CRISPR-based solutions and beyond, we offer a broad portfolio designed to support diverse research workflows. What truly sets us apart is our commitment to close, fast, and personal customer support. We help you find the best-fit solutions for your experimental setup, keep you informed every step of the way, and ensure your project runs smoothly from start to finish.

At a Glance

Founded

January of 2020

Location

Heidelberg, Germany

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Customers

Academia & Industry

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Focus

Reagents & Services

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What We Do

At Nucleus Biotech, we provide enabling reagents and services that power life science research in both academia and industry. As a specialized distributor and scientific partner, we bring together a comprehensive portfolio of cutting-edge tools – from CRISPR genome editing and NGS library preparation to custom gene synthesis and immunogenomics solutions. Whether you’re optimizing routine lab workflows or tackling complex challenges like target discovery screens, liquid biopsy analyses, or high-throughput functional genomics projects, we’re here to support you every step of the way. Our team doesn’t just deliver products—we provide expert guidance, helping you select the right tools, troubleshoot experimental setups, and navigate even the most demanding applications with confidence.

CRISPR Tools

Complete solutions for genome engineering, including pooled and arrayed lentiviral sgRNA libraries, Cas proteins and mRNA, and synthetic gRNA – for CRISPR knockout, activation, inhibition, Perturb-Seq applications, as well as CRISPRDx.

Gene Synthesis Services

Custom gene and gene fragment synthesis with documented sequence verification, flexible vector options, and optional large scale high purity plasmid preparation – paired with competitive pricing and excellent support from request to delivery.

Next Generation Sequencing

Broad NGS portfolio featuring immune repertoire profiling, amplicon and hybridization capture panels, long-read sequencing, Hi-C kits, microbiome profiling, and library prep solutions for DNA and RNA applications.

RNA Genomics

Advanced RNA analysis tools including small RNA-seq, targeted RNA-seq and RBP targetome sequencing. Premade and customized synthetic mRNAs, circRNAs, saRNAs, and LNP-based RNA delivery solutions.

Immunogenomics

Next-generation solutions for adaptive immune system research: Bulk and single-cell TCR & BCR sequencing for clonotype screening as well as obtaining chain pairing information. Services for receptor chain synthesis and cloning, Engineered reporter cell systems for detecting antigen-receptor interactions. Synthetic mRNAs for expression of antibody-, CAR-, and ADC-targets.

Liquid Biopsy

Specialized kits and reagents for non-invasive biomarker detection from blood and body fluids, including sample collection tubes, cf-DNA/RNA isolation, exosome purification, cf-RNA seq kits, and sensitive NGS panels for cancer mutation detection.

Lentiviral Systems

High-efficiency lentiviral tools for stable expression in any cell type: Packaging, concentration, and transduction reagents, cloning vectors, production services, and genome-wide shRNA, sgRNA, and ORF libraries as well as individual lentiviral expression constructs and clones.

Cell Barcoding

Lentiviral barcode libraries for lineage tracing, cell fate mapping, and high-throughput screening – compatible with genomic DNA and RNA-seq readouts.

Sample Collection

Innovative iSWAB devices for non-invasive collection and room-temperature preservation of microbiomes, DNA, RNA, and cells, plus HemaSure-OMICS all-in-one liquid biopsy tubes for blood collection and preservation of cf-DNA and cells at room temperature.

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Our Team

We’re a small team, and that’s by choice. At Nucleus Biotech, you won’t navigate through layers of sales reps or support tickets. Instead, you work directly with people who know the science, understand the products, and have spent years in the field. We stay lean so we can stay close – to new technologies, to our customers, and to what actually works in the lab.

Dr. Michael Ehret

Managing Director & Scientific Consultant

Michael has been in the biotech industry since 1986, working his way through Stratagene, Clontech and founding the BioCat GmbH in 2000 – a successful life science distributor he built and sold in 2017. But after nearly 20 years running BioCat, he realized he missed the direct customer contact and closeness to cutting-edge technologies. That’s why he founded Nucleus Biotech in 2020: to get back to what he loves – working hands-on with customers on challenging projects, advising on CRISPR screens, NGS workflows, liquid biopsy setups, and custom gene synthesis, and helping labs figure out which products actually fit their needs. When he’s not scouting for the next innovative technology, Michael is passionate about basketball and enjoys cultivating exotic plants in his garden – including banana trees that, despite his best efforts, haven’t produced edible fruit yet.

Elke Gamer

Product Manager

Elke studied biology and completed her PhD in 1993 in Heidelberg and Hamburg, followed by a PostDoc at the Institute of Human Genetics. From there, she made the move into the life science supplier industry – drawn to the variety, the customer contact, and the chance to work with a broader range of technologies and methods. Her first stop? Stratagene in Heidelberg, where she quite literally took over the desk from Michael. After Stratagene, she joined Hybaid, a supplier of enzymes, thermocyclers and PCR kits. When Michael founded BioCat, Elke came on board as employee number three. She stayed for 17 years, growing with the company, before joining Michael again when he founded Nucleus Biotech in 2020. When she’s not helping customers navigate their next experiment, Elke loves dancing – both ballroom and jazz/Zumba – hiking, and going for walks with her dog.

Partners & Technology Sources

We partner with companies developing the technologies we believe in—the ones solving real problems in genomics, screening, and diagnostics. Our job is to bring these advanced methods to labs across Europe and make sure you have the support and expertise to use them successfully

BioDynami (USA)

NGS Library Preparation

Celemics (South Korea)

Hyb-Capture NGS Solutions

Cellecta (USA)

CRISPR/RNAi & Immune Repertoire Profiling

Eclipse BioInnovations (USA)

RNA Genomics Sequencing

Heidelberg Biolabs (Germany)

Cell-free RNA Analysis

Levostar (USA & China)

RNA & DNA Synthesis

Mawi (USA)

Sample Collection

Nexotech (Spain)

Exosome Purification Kits

Paragon Genomics (USA)

NGS Panels

Phase Genomics (USA)

Hi-C Sequencing Kits

Skyang Bio (USA)

Clone Collections & Libraries

Synbio Technologies (USA & China)

Synthetic Biology

Trialtus Bioscience Technologies (USA)

Recombinant Proteins

Universal Sequencing Technology (USA)

TELL-Seq Kits