ACE2, TMPRSS2, CD147, NRP1 and DPP4 are the main entry factors in human host cells for infection wirth SARS and MERS. These factors mediate binding and entry of the Spike protein expressed by the SARS and MERS virus.
We offer lentiviral constructs enabling the over-expression of these proteins in any cell type, including primary cells. You can study SARS-Cov-2 and MERS host cell interactions and screen for potential virus entry inhibitors.
The lentiviral constructs are available as plasmid DNA or as lentiviral particles. The entry factors can be expressed constitutively or tetracycline induced.